Clozapine 200

Armin Moradi

2021-04-15

Previously on Clozapine…

  • amoradi.org/public/clozapine.html
  • amoradi.org/public/clozapine2.html

Effects and side effects

  • maaaaaaaaaaaany

Sedation

  • Most common adverse drug reaction
  • can happen after titration

Sedation - treatment

  • qHS
  • slow titration
  • minimize sedating agents

Sedation - treatment 2.0

  • reduce dose
  • aripiprazole
  • stimulants

Sedation - What to do

  • staaaahp benzo, antichol
  • 500 qHS
  • titration

Orthostasis

  • systolic 20, diastolic 10
  • alpha1

Orthostasis - treatment

  • remove/reduce antihypertensives
  • dose adjustment
  • fluid intake
  • fludrocortisone 0.1

Tachycardia

>100

Tachycardia - What to do

  • orthostasis?
  • antichol? adrenergic?
  • infection? pain? illness?
  • first 6 months: myocarditis?
  • if not, atenolol 12.5

Summary

  • many side effects
  • to be continued!