Alcohol from 10,000 ft

Armin Moradi

2020-08-07

Epidemiology

  • 90%
  • 60-70%
  • 40%+
  • 10/5%
  • 100000

Comorbidity

  • Antisocial
  • Mood
  • Anxiety
  • Suicide

Etiology

  • Bio
  • Psycho
  • Social

Absorption

  • 10% stomach
  • 90% small intestine
  • 30-90min lag (usually 30-45mins)
  • most rapid 15-30% alcohol
  • too high of a concentration: pylorospasm -> N/V

Metabolism

  • 90% liver oxidation -> constant rate ~10-34mg/dL/hr
  • 10% kidney and lungs
  • alcohol dehydrogenase: alcohol -> acetaldehyde (toxic)
  • aldehyde dehydrogenase: acetaldehyde -> acetic acid

Effects

  • fly high
  • wings better than redbull

Effects 2.0

  • Brain
  • Behaviour
  • Sleep

Effects 2.0 cont'd

  • 0.05% -> thought, judgement, restraint are loosened
  • 0.1% -> clumsy voluntary motor actions
  • 0.1-0.15% -> legal intoxication
  • 0.2% -> entire motor depression
  • 0.3% -> confusion and stupor
  • 0.4-0.5% -> coma
  • >0.5% -> death due to respiratory depression, aspiration, etc

Dependence

  • Alcohol use disorder: DSM-V
  • So many types!

Withdrawal

  • tremulousness
  • psychotic and perceptual symptoms
  • seizure
  • delirium tremens
  • irritability
  • GI symptoms (N/V)
  • sympathetic hyperactivity

Withdrawal treatment

  • Benzodiazepines

All done

^_^